Methimazole, Carbimazole, And Congenital Skin Defects

The document discussed concerns about the use of methimazole, an antithyroid drug, during pregnancy due to its potential association with congenital skin defects, specifically aplasia cutis. Two studies highlighted this risk, with one study from 1972 describing 12 cases of congenital scalp defects, where methimazole was used by the mothers in three instances, including a case with fraternal twins. The document suggested caution in prescribing methimazole to pregnant women with hyperthyroidism, as noted by reviews from Burrow and Cooper.