Influence of Intestinal Microbiota Imbalances on Androgenetic and Areata Alopecia: A Narrative Literature Review

October 2025 in “ Scientia Generalis ”

I.R.M.D.A. Lima, Fernanda Gonçalves Silva

alopecia androgenética alopecia areata microbiota intestinal disbiose andrógenos resposta imune

TLDR Balancing gut bacteria may help prevent and treat certain types of hair loss.

Este trabalho revisa a literatura sobre a influência dos desequilíbrios da microbiota intestinal nas alopecias androgenética e areata, destacando a relevância do equilíbrio intestinal nos processos metabólicos, hormonais e imunológicos. Estudos recentes sugerem que a disbiose está relacionada ao desenvolvimento de doenças crônicas, inflamatórias e autoimunes, incluindo alopecias. A revisão narrativa indica que a disbiose pode alterar o metabolismo de andrógenos e a resposta imune, sugerindo que o equilíbrio intestinal pode ser benéfico na prevenção e tratamento dessas condições, promovendo novas abordagens terapêuticas e melhorando a qualidade de vida dos afetados.

View this study on scientiageneralis.com.br →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research The Multi-Faceted Role of Gut Microbiota in Alopecia Areata

3 citations , June 2025 in “Biomedicines”

Microbial Dysbiosis and Its Diagnostic Potential in Androgenetic Alopecia: Insights from Multi-Kingdom Sequencing and Machine Learning

research Microbial Dysbiosis and Its Diagnostic Potential in Androgenetic Alopecia: Insights from Multi-Kingdom Sequencing and Machine Learning

May 2025 in “mSystems”

Microbial imbalances on the scalp can help diagnose and manage hair loss early.

research Causal Relationship Between Gut Microbiota and Androgenetic Alopecia: A Mendelian Randomization Study

December 2024 in “Medicine”

Gut bacteria may affect hair loss risk.

research Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia

August 2024 in “Nutrients”

Probiotics help reduce hair loss and increase hair growth in people with androgenic alopecia.

research Exploring the Role of Gut Microbiota in Patients with Alopecia Areata

10 citations , April 2024 in “International Journal of Molecular Sciences”

Gut bacteria differences may influence alopecia areata.

research Roles of Gut Microbiota in Androgenetic Alopecia: Insights from Mendelian Randomization Analysis

April 2024 in “Frontiers in microbiology”

Certain gut bacteria may increase or decrease the risk of male pattern baldness.

research The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

February 2024 in “International Journal of Molecular Sciences”

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

research Female Androgenetic Alopecia – The Impact on Self-Esteem

1 citations , October 2023 in “RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218”

Alopecia androgenética in women can lower self-esteem and cause mental health issues.

research Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

June 2023 in “Clinica Chimica Acta”

Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

4 citations , October 2022 in “Genes”

Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.

research Gut Microbiota in Alopecia Areata

13 citations , January 2022 in “Advances in Dermatology and Allergology”

Alopecia areata may be linked to imbalanced gut bacteria.

research Hair Regrowth Following Fecal Microbiota Transplantation in an Elderly Patient with Alopecia Areata: A Case Report and Review of the Literature

40 citations , September 2019 in “World journal of clinical cases”

An elderly man's hair grew back after a treatment that transferred healthy gut bacteria.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations , January 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

Related Community Posts Join

6 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Is my routine good enough?

in Finasteride 226 upvotes 3 months ago

A 29-year-old is experiencing diffuse hair loss and has been using minoxidil without success. They are now trying a routine with oral minoxidil, topical finasteride, and dermarolling, but are unsure about the effectiveness and legitimacy of the products.

community AGA evaluation and first steps - BEGINNER MEGAPOST

in Chat 80 upvotes 1 year ago

The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

community Nearly 40% of Adults with Alopecia Areata Taking OLUMIANT® 4-mg Saw at Least 80% Scalp Hair Coverage at 52 Weeks

in Research/Science 6 upvotes 3 years ago

Nearly 40% of adults with alopecia areata achieved at least 80% scalp hair coverage after 52 weeks of taking OLUMIANT® 4-mg. The conversation distinguishes this success from androgenetic alopecia, which is a different type of hair loss.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 676 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Hope Medicine announces HMI-115 phase II clinical trial for androgenetic alopecia in China

in Research/Science 56 upvotes 2 years ago

Hope Medicine's announcement of the HMI-115 Phase II clinical trial for androgenetic alopecia in China; other related trials have been conducted or are ongoing in different countries, including Australia, US, and Europe. There is speculation that the product may be accepted across borders without additional testing.

Similar Research

5 / 1000+ results

research Understanding the Impact of the Skin Microbiome on Dermatological Assessments and Therapeutic Innovation

November 2025 in “Dermato”

The skin microbiome is crucial for skin health and new treatments like probiotics can improve skin conditions.

research Influence of Dysbiosis on Scalp Pathology

December 2021 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia”

Imbalance in scalp bacteria can affect hair and scalp health, potentially leading to conditions like hair loss, psoriasis, and dandruff.

Alopecia and Microbiome: Future Therapeutic Target?