Microneedle Array Patch Made of Kangfuxin/Chitosan/Fucoidan Complex Enables Full-Thickness Wound Healing

January 2022 in “ Frontiers in Chemistry ”

Xixi Yu, Caixia Wang, Yuanfei Wang, Longhao Li, Xiang Gao, Tingting Zhu, Pu-Gen An, Zhaojian Meng, Wanchun Wang, Tong Wu, Yuanping Hao

microneedle array patch kangfuxin chitosan fucoidan stratum corneum transdermal drug delivery epithelial thickness collagen deposition marine polysaccharides traditional Chinese medicine

TLDR The patch speeds up deep wound healing.

The study developed a microneedle array patch made from a Kangfuxin/Chitosan/Fucoidan complex (KCFMN) to enhance full-thickness wound healing. The KCFMN patch showed excellent biocompatibility and antibacterial properties, with nearly 100% inhibition of E. coli and 80% inhibition of S. aureus. In vivo experiments on rats demonstrated that the KCFMN patch significantly improved wound healing compared to other treatments, particularly on days 7 and 9, due to a slow-release effect. Histological analysis revealed faster re-epithelialization and increased collagen deposition, indicating enhanced wound healing capabilities. The study concluded that the KCFMN patch was a promising approach for effective wound healing.

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