Importance of MicroRNAs in Skin Morphogenesis and Diseases

The document reviewed the role of microRNAs (miRNAs) in skin morphogenesis and diseases. miRNAs, which are small non-coding RNAs, played a crucial role in post-transcriptional gene silencing by binding to target mRNAs. They were involved in various skin-related processes, including hair follicle morphogenesis, where their absence in keratinocytes led to defects. miRNAs were also implicated in psoriasis, autoimmune skin diseases like SLE and ITP, wound healing, and skin carcinogenesis. Specific miRNAs, such as miR-21, were identified as potential oncogenic factors. The research highlighted the potential of miRNAs as therapeutic targets and diagnostic biomarkers for skin conditions.