Minoxidil and Dexamethasone Eluting Nanofiber Dressing for Cutaneous Wound Healing in Rat

December 2022 in “ ̒Ulūm-i dārūyī ”

Saber Khosan, Behsa Salehian, Fatemeh Montaghimi, Yaeghob Sharifi, Anahita Fathi Azarbayjani

minoxidil dexamethasone nanofiber dressing anagen hair growth phase corticosteroids collagen production wound healing scar formation Rogaine

TLDR The new wound dressing with minoxidil and dexamethasone could speed up healing and reduce scarring in rats.

The study aimed to develop a nanofiber dressing that elutes minoxidil and dexamethasone for wound healing in rats. Minoxidil is known to promote blood flow, which may speed up wound closure, while corticosteroids like dexamethasone can down-regulate healing. The developed dressings were characterized using SEM and FT-IR, and drug release was studied over 12 days. In the rat model, wounds treated with minoxidil showed good healing activity, likely due to the promotion of anagen hair growth phase, while dexamethasone was found to suppress collagen production and prevent scar formation. The study concludes that the minoxidil and dexamethasone-eluting wound dressing has the potential to be a new clinical treatment to accelerate wound healing and prevent scarring.