Method Development and Estimation of Minoxidil by Gas Chromatography

The document discusses the development and validation of a Gas Chromatography-Flame Ionization Detection (GC-FID) method for estimating minoxidil in pharmaceutical formulations and biological matrices. This method involves liquid-liquid extraction and derivatization to enhance volatility, showing good linearity, precision, accuracy, and specificity. It is presented as a suitable alternative to High-Performance Liquid Chromatography (HPLC) for routine quality control or pharmacokinetic studies, with hypothetical validation data confirming compliance with ICH Q2 (R1) guidelines.