Efficacy of 5% Topical Minoxidil Alone Versus Combination with Microneedling and PRP in Androgenetic Alopecia

June 2025

Dr. Harmeet Singh, Dr. Minakshi Narah, Dr. Krishna Talukdar, Dr. Balu Haridas, Dr. Porimollika Boruah, Dr. Aparajita Roy, Dr. Pallabi Hatikakoty

androgenetic alopecia 5% topical minoxidil minoxidil microneedling platelet-rich plasma PRP Hamilton–Norwood grading pruritus seborrheic dermatitis Rogaine

TLDR The combination of minoxidil, microneedling, and PRP is more effective for hair growth than minoxidil alone.

A study involving 50 patients with androgenetic alopecia compared the efficacy of 5% topical minoxidil alone (Group A) versus a combination of minoxidil, microneedling, and platelet-rich plasma (PRP) (Group B). Results showed that Group B had significantly better outcomes after 6 months, with improvements assessed through patient self-evaluation, photographs, and Hamilton–Norwood grading. Mild adverse effects were reported, including pruritus, seborrheic dermatitis, and headache. The study concludes that the combination treatment is more effective than minoxidil alone, suggesting PRP as a safe and effective adjunct, though further research with standardized protocols is needed.

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