MiR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

April 2022 in “ Genes ”

Fan Yao, Bohao Zhao, Shuaishuai Hu, Shaocheng Bai, Rongshuai Jin, Chen Zhang, Yang Chen, Xinsheng Wu

miR-129-5p HOXC13 hair follicle growth SFRP2 TGF-β1 FGF2 dermal papilla cells apoptosis proliferation transforming growth factor beta 1 fibroblast growth factor 2

TLDR miR-129-5p affects hair growth by targeting the HOXC13 gene.

The study, involving 15 rabbits, explored the role of miR-129-5p in hair follicle growth by targeting the HOXC13 gene. It was found that miR-129-5p was overexpressed during the catagen phase and negatively correlated with HOXC13 expression. Overexpression of miR-129-5p inhibited hair follicle development-related genes and promoted apoptosis in dermal papilla cells, while its inhibition had the opposite effect. These findings suggested that miR-129-5p played a significant role in regulating hair follicle growth by modulating HOXC13, providing insights into potential genetic improvements for animal hair quality and new approaches for diagnosing and treating human hair loss.

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MiR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

Research cited in this study

research Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production

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research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

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research Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation

research A Homozygous Frameshift Mutation in the HOXC13 Gene Underlies Pure Hair and Nail Ectodermal Dysplasia in a Syrian Family

research Loss-Of-Function Mutations In HOXC13 Cause Pure Hair And Nail Ectodermal Dysplasia

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research Krtap16: Characterization of a New Hair Keratin-Associated Protein Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13

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