MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5

The study explored the role of miR-339-5p in the differentiation of hair follicle stem cells (HFSCs) induced by loureirin A, revealing that miR-339-5p acted as a negative regulator by targeting the DLX5 gene. Downregulation of miR-339-5p increased DLX5 expression and promoted HFSC differentiation, implicating the Wnt/β-catenin signaling pathway in this process. These findings suggested that miR-339-5p and DLX5 could be potential therapeutic targets for skin repair and regeneration, offering insights into molecular mechanisms that could impact hair growth and regeneration.