The Study of miRNA-211 Affects Melanogenesis Progress in Cashmere Goats via Suppressing AP1S2

February 2025 in “ Archives animal breeding/Archiv für Tierzucht ”

Baoyu Zhang, R.‐Y. Liu, Tao Ma, Xinyu Li, Yang Zhao, H. Su, Jianping Li, Yumei Li, Huaizhi Jiang, Qiaoling Zhang

miRNA-211 melanogenesis AP1S2 melanin B16-F10 cells

TLDR miRNA-211 reduces melanin in Cashmere goats by suppressing AP1S2.

The study investigates the role of miRNA-211 in the melanogenesis of Cashmere goats by targeting the AP1S2 gene. Through various experiments, including dual-luciferase reporter assays and RT-qPCR, it was found that miRNA-211 downregulates AP1S2 expression. This downregulation was confirmed in B16-F10 cells and goat skin, showing opposite expression trends between miRNA-211 and AP1S2. Animal regression studies further confirmed that miRNA-211 affects melanogenesis by reducing melanin content in the skin. The study concludes that miRNA-211 significantly influences the melanogenesis process in Cashmere goats by suppressing AP1S2, thereby affecting the melanin content in their skin.

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