Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells
December 1991
in “
Annals of the New York Academy of Sciences
”
keratinocytes epidermis hair follicle outer root sheath matrix cells keratin profiles differentiation markers soft keratins alpha-keratins stratified epithelia epidermal differentiation markers normal keratinocytes tissue homeostasis Matrigel human dermal fibroblasts follicular dermal papilla cells ORS NEK HDF DP cells
TLDR ORS and hair matrix cells balance growth and differentiation better than normal keratinocytes, with human dermal fibroblasts crucial for proper differentiation.
The study investigated the modulation of the differentiated phenotype of keratinocytes derived from the epidermis and hair follicle outer root sheath and matrix cells. Researchers aimed to understand how these cells could be experimentally altered, which was significant for potential applications in dermatology and hair research. The study involved various experimental conditions to observe changes in keratinocyte behavior and differentiation. The findings contributed to the understanding of keratinocyte biology and their potential manipulation for therapeutic purposes, although specific details on the number of participants or experimental subjects were not provided.
