Construction And Identification Of Mouse Model With Conditional Knockout Of P75 Neurotrophin Receptor Gene In Epidermal Cells By Cre-LoxP System

The study successfully constructed a mouse model with a conditional knockout of the p75 neurotrophin receptor (p75NTR) gene in epidermal cells using the Cre-loxP system. The research involved breeding 20 second-generation mice, of which 4 were complete p75NTR gene knockout mice. The expression of p75NTR was absent in the skin epidermis of knockout mice but present in wild-type mice, while both types showed p75NTR expression in brain tissue. No abnormal growth or changes in skin histomorphology were observed in knockout mice, indicating that the Cre-loxP system effectively created the knockout model without affecting skin structure.