Multi-target evaluation of Korean herbal compounds against the SRD5A2 / AR / beta-catenin axis for androgenetic alopecia: Boltz-2 cofold, ChEMBL-anchored ranking, ADMET-AI 107-endpoint safety panel, and pilosebaceous single-cell atlas-constrained prioritization of Saponin Re, Emodin, and Biochanin A
July 2026
in “
Zenodo (CERN European Organization for Nuclear Research)
”
TLDR Biochanin A is the safest herbal compound for potential hair loss treatment.
This study evaluates Korean herbal compounds for their potential in treating androgenetic alopecia (AGA) by targeting the SRD5A2, AR, and beta-catenin pathways using an in silico framework. The research identifies Saponin Re from Panax ginseng and Emodin from Polygonum multiflorum as top candidates based on affinity, though both have safety concerns. Biochanin A from soy and Astragalus membranaceus is highlighted as the safest option. The study emphasizes that all findings are computational, with no experimental or clinical validation, and suggests further testing in dermal papilla cell cultures and scalp organoids.
