The Identification of Multi-Target Inhibitors of Wolbachia Pipientis and Onchocerca Volvulus by Molecular Simulations

The study focuses on identifying potential drug targets for Onchocerca volvulus and its endosymbiont Wolbachia pipientis, which cause human Onchocerciasis, a major public health issue in sub-Saharan Africa and Latin America. Using molecular docking simulations, 2,015 approved drugs were screened, leading to the identification of Adapalene, Diosmin, and Azelastine as promising multi-target inhibitors. Other compounds like Drospirenone, Alectinib, Dutasteride, and Finasteride also showed potential. The study concludes that repurposing these drugs could offer effective treatment options for onchocerciasis, with further research needed to confirm their efficacy.