Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

    February 2023 in “ Polymers
    Mahsa Sedighi, Neha Shrestha, Zahra Mahmoudi, Zahra Khademi, Alireza Ghasempour, Hamideh Dehghan, Seyedeh Fahimeh Talebi, Maryam Toolabi, Véronique Préat, Bo Zhi Chen, Xindong Guo, Mohammad‐Ali Shahbazi
    TLDR Peptide hydrogels are promising for drug delivery and tissue repair in medicine.
    The document reviews the potential of multifunctional self-assembled peptide hydrogels in various biomedical applications due to their bioactivity, biocompatibility, and biodegradability. These hydrogels can mimic natural tissue environments and respond to stimuli for controlled drug release, making them suitable for regenerative medicine, drug delivery, tissue engineering, and wound healing. They are formed through various intra-peptide interactions, allowing for diverse structures and applications, including targeted drug and gene delivery, stem cell therapy, cancer therapy, immune regulation, bioimaging, and regenerative medicine. Despite their advantages, further research is needed to address challenges such as clinical translation and physiological relevance.
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