Myo-Inositol for Cutaneous Manifestations of Polycystic Ovary Syndrome: An International Delphi Consensus Recommendation for Dermatology Practice

June 2026 in “ Cureus ”

Anil Ganjoo, Sanjay Kalra, Malavika Kohli, Rajetha Damisetty, Sachin Verma, Rajat Kandhari, Balram Sharma, Nilakshi Deka, Anne Beatrice, Ambika Rani Pradhan, Sudip Parajuli, Haikal A Rahman, Sarker Mahbub A Shamim, Rathish Nair, Pratik Patel, Girish R. Kulkarni

Myo-inositol polycystic ovary syndrome PCOS acne hirsutism folic acid vitamin D3 D-chiro-inositol metabolic dysfunction hyperandrogenism MI vitamin D

The study aimed to establish expert consensus on using Myo-inositol (MI) for managing dermatologic symptoms of polycystic ovary syndrome (PCOS), such as acne and hirsutism. Through a Delphi process involving 133 experts, consensus was reached that MI is an effective and well-tolerated treatment for these symptoms. It is recommended to use MI at a dosage of 4 g/day for at least 6 months. Additionally, combinations of MI with folic acid and vitamin D₃, or with D-chiro-inositol, are preferred for addressing metabolic dysfunction and hyperandrogenism. The study suggests integrating MI-based therapy into the comprehensive management of PCOS-related skin issues.

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research Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women

37 citations , October 2024 in “JAMA Network Open”

PCOS is common among Indian women, often with metabolic issues, needing better management strategies.

research Update on the Combination of Myo-Inositol/D-Chiro-Inositol for the Treatment of Polycystic Ovary Syndrome

11 citations , January 2024 in “Gynecological Endocrinology”

Myo-inositol and D-chiro-inositol, especially in a 40:1 ratio, effectively treat PCOS by improving insulin sensitivity and ovulation.

Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

8 citations , August 2023 in “The Journal of Clinical Endocrinology and Metabolism”

Follow the latest international guidelines to assess and manage Polycystic Ovary Syndrome effectively.

Efficacy and Safety of Tracnil Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study

research Efficacy and Safety of Tracnil Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study

3 citations , March 2020 in “Dermatology Research and Practice”

Tracnil™, a mix of myo-inositol, folic acid, and vitamin D3, safely reduced acne, improved excessive hair growth, and fixed irregular periods in overweight women with PCOS.

research Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study

28 citations , January 2017 in “Indian Dermatology Online Journal”

Skin problems like acne, excessive hair growth, and oily skin are common in women with PCOS and can help with early diagnosis.

research Polycystic Ovary Syndrome: A Review for Dermatologists

60 citations , October 2014 in “Journal of the American Academy of Dermatology”

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

research Potential Role and Therapeutic Interests of Myo-Inositol in Metabolic Diseases

369 citations , June 2013 in “Biochimie”

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

research Efficacy of Myo-Inositol in the Treatment of Cutaneous Disorders in Young Women with Polycystic Ovary Syndrome

64 citations , January 2009 in “Gynecological Endocrinology”

Myo-inositol helps improve skin conditions and metabolic profiles in young women with PCOS.

research Hirsutism

271 citations , December 2005 in “New England journal of medicine/The New England journal of medicine”

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.

research Acne: Hormonal Concepts and Therapy

118 citations , September 2004 in “Clinics in Dermatology”

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

research Hirsutism and Acne in Polycystic Ovary Syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.