The Emerging Roles of N6-Methyladenosine (m6A) Deregulation in Polycystic Ovary Syndrome

May 2025 in “ Journal of Ovarian Research ”

L N Jiang, Jiaying Xiao, Liangzhen Xie, Feifei Zheng, Fangliang Ge, Xue Zhao, Rong Qiang, Jie Fang, Zhihong Liu, Zihan Xu, Ran Chen, D. Wang, Yanfeng Liu, Qing Xia

TLDR m6A deregulation plays a key role in PCOS and could lead to new treatments.

The document explores the role of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome (PCOS), emphasizing its impact on reproductive and metabolic processes. m6A modifications, involving proteins like METTL3 and FTO, are crucial in PCOS pathogenesis, affecting ovulation, endometrial receptivity, and chronic inflammation. The study highlights the potential of m6A-related proteins as biomarkers and therapeutic targets, with treatments like metformin, anti-androgens, and psychological therapy addressing various PCOS symptoms. The document also discusses the influence of gut flora on PCOS and the promise of therapies like Chinese herbs, probiotics, and phytochemicals in managing the condition. Further research is needed to develop targeted therapies for PCOS.

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The Emerging Roles of N6-Methyladenosine (m6A) Deregulation in Polycystic Ovary Syndrome

Research cited in this study

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research PCOS and Depression: Common Links and Potential Targets

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research Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature

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