Topical Delivery of Nanoemulsions for Skin Cancer Treatment

The document explores the potential of nanoemulsions (NEs) as a promising alternative for the topical treatment of skin cancer, offering advantages such as enhanced drug solubility, stability, and targeted delivery, which improve therapeutic outcomes while minimizing systemic toxicity. Various studies demonstrate that NEs can penetrate deeper into the skin, effectively delivering drugs like leflunomide, daidzein, and 5-fluorouracil, showing significant anti-melanoma activity and improved drug permeation. Despite their promise, challenges such as long-term stability, toxicity concerns, and regulatory hurdles remain. The review suggests that continued research and investment are crucial for overcoming these challenges and realizing the full potential of NEs in skin cancer treatment.