Design and Development of Epigallocatechin Gallate and Fenugreek Seed Extract Loaded Nanosponge-Based Aloe Vera Gel for Treating Alopecia Areata

The study focuses on developing a nanosponge-based aloe vera gel incorporating Epigallocatechin gallate (EGCG) and fenugreek seed extract (FSE) to treat Alopecia Areata. EGCG, a potent antioxidant from green tea, faces challenges like poor stability and permeability, while fenugreek seeds are known to promote hair growth by affecting dihydrotestosterone synthesis. Aloe vera is recognized for its nourishing properties that support hair health. The research aimed to enhance the delivery and efficacy of these compounds using a nanosponge system, which offers controlled drug release, stability, and improved cellular uptake. Ethyl cellulose and polyvinyl alcohol were used in the synthesis, and the formulation was optimized for particle size, encapsulation efficiency, and drug release.