Nanozyme Catalysis Restores Hair Follicle Integrity by Reversing Peroxisomal Collapse

This study identifies peroxisomal dysfunction as a key factor in hair follicle degeneration and alopecia, highlighting its role in disrupting metabolic and oxidative processes. Researchers found that peroxisome-associated pathways were downregulated in alopecia patients, and similar dysfunctions were observed in <i>Nudt7</i>-deficient mice, leading to hair thinning and oxidative stress. To counteract this, catalytic nanozymes (HA-Hem) were developed to mimic peroxisomal catalase activity, restoring metabolic balance and promoting hair regeneration in murine models. Nanozyme treatment enhanced PPARα expression, improving peroxisomal and mitochondrial function and outperforming minoxidil in regenerative efficacy. These results suggest that targeting peroxisomal function could be a promising therapeutic strategy for alopecia.