Can Nanozymes Make the Leap to the Clinic? Advances, Hurdles, and Prospects

Nanozymes, which are versatile artificial enzymes, hold promise for biomedical applications due to their customizable catalytic, diagnostic, and therapeutic functions. However, their clinical translation is hindered by challenges such as limited mechanistic understanding, safety and biodegradability concerns, and regulatory hurdles. The review suggests that single-material nanozyme platforms could serve as practical foundations for clinical use, and their integration into advanced microrobotic systems could enhance precision theranostics. It emphasizes the importance of future studies on human efficacy and safety to expedite clinical translation and commercialization.