Nephronectin Is Correlated With Poor Prognosis In Breast Cancer And Promotes Metastasis Via Its Integrin-Binding Motifs

    April 2018 in “ DSpace@MIT (Massachusetts Institute of Technology) ”
    Jimita Toraskar, Richard P. Redvers, Marit Valla, Synnøve Norvoll Magnussen, Anna M. Bofin, Signe Opdahl, Steinar Lundgren, Bedrich L. Eckhardt, Judy P. Doherty, Robin L. Anderson, Gunbjørg Svineng, Tonje S. Steigedal, John M. Lamar, Richard O. Hynes
    TLDR Nephronectin is linked to worse outcomes in breast cancer and helps cancer spread.
    The study analyzed nephronectin (NPNT) expression in breast cancer tissue from 842 patients and found that granular cytoplasmic staining of NPNT in less than 10% of tumor cells was associated with poor prognosis. NPNT was suggested to promote metastasis through its integrin-binding motifs, enhancing adhesion and anchorage-independent growth, and facilitating lung colonization by breast tumor cells. The findings indicated that NPNT could serve as a novel prognostic marker for a subgroup of breast cancer patients.
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