Neuroendocrine Pathways in Skin Health and Homeostasis: A Systematic Review

April 2026 in “ Journal of Dermatology Research ”

Elizabeth Kream, Rachel Shireen Golpanian, Anna‐Marie Hosking, Monica Boen, Sabrina G. Fabi

neuropeptide neurotransmitter melatonin substance P oxytocin neurohormonal signaling anti-inflammatory psychodermatologic

TLDR The skin communicates with the nervous system, and targeting neurohormones like melatonin and oxytocin could help treat skin issues.

This systematic review highlights the emerging role of the skin as a neuroendocrine organ and its communication with the nervous system, emphasizing the potential of neuropeptide- and neurotransmitter-based interventions in dermatology. Analyzing 68 studies, primarily preclinical with some randomized controlled trials, the review identifies melatonin, substance P modulation, and oxytocin as key neuroendocrine mediators with consistent evidence supporting their anti-inflammatory, reparative, and psychodermatologic benefits. These findings suggest that neurohormonal signaling could be a promising therapeutic target for both skin disease management and aesthetic applications.