Role of Neurosteroids in Dopaminergic Modulation

    May 2015
    Deleted Author ID
    TLDR Neurosteroids help control dopamine responses in the brain.
    The document presented evidence that neurosteroids significantly influenced dopaminergic responses in the brain. It highlighted that inhibiting 5 alpha-reductase (5AR), an enzyme crucial for neurosteroid synthesis, produced antidopaminergic effects. The study focused on finasteride (FIN), a 5AR inhibitor used for benign prostatic hyperplasia and androgenic alopecia, which in rodents reduced behavioral issues caused by dopaminergic agents without causing catalepsy or extrapyramidal side effects. The research extended to examining other neurosteroidogenic enzymes in Sprague-Dawley rats, using a probability discounting task to explore behavioral aspects of gambling disorder.
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      community Finasteride does deplete important nuero-active steroids

      in Research/Science  11 upvotes 2 years ago
      Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

      community I've been afflicted by post finasteride syndrome, what now?

      in Finasteride  41 upvotes 7 years ago
      A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  109 upvotes 1 week ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

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