Nevus Sebaceous: Histopathological Examination

    January 2025 in “ Indian Journal of Dermatopathology and Diagnostic Dermatology ”
    Gopalsing Rameshsing Rajput, Archana Reddy, Anıl Kumar, Ann Maria Paulose
    The histopathological examination of nevus sebaceous (NS) reveals distinct features such as focal epidermal acanthosis, papillomatosis, and a significant reduction in hair follicle density, with remaining follicles being rudimentary and some filled with keratin. The dermis contains numerous mature sebaceous glands, often lacking visible ducts, and scarce apocrine glands located beneath the sebaceous units. A basaloid arrangement of follicular germinative cells indicates adnexal epithelial proliferation. These characteristics—sebaceous hyperplasia, immature follicular units, and basaloid adnexal elements—are indicative of NS and help differentiate it from other conditions like sebaceous hyperplasia, basal cell carcinoma, trichoblastoma, syringocystadenoma papilliferum, follicular hamartoma, and epidermal nevus. The integration of epidermal, sebaceous, follicular, and apocrine alterations is crucial for a definitive diagnosis of NS.
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