Endothelial NMMHC IIA Dissociation From PAR1 Activates the CREB3/ARF4 Signaling in Thrombin-Mediated Intracerebral Hemorrhage

    November 2024 in “ Journal of Advanced Research ”
    Yujie Dai, Lei Bao, Juan Huang, Miling Zhang, Xiaohong Yu, Yuanyuan Zhang, Fang Li, Boyang Yu, Shuaishuai Gong, Junping Kou
    TLDR Targeting NMMHC IIA may help treat blood-brain barrier damage.
    The study found that the dissociation of NMMHC IIA from PAR1 activates the CREB3/ARF4 signaling pathway, which exacerbates blood-brain barrier (BBB) damage caused by thrombin. This discovery suggests that NMMHC IIA could be a new therapeutic target for treating diseases related to BBB damage.
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