Nanomilled Oral Testosterone Plus Dutasteride Effectively Normalizes Serum Testosterone in Normal Men With Induced Hypogonadism

    February 2008 in “ International Journal of Andrology ”
    Stephanie T. Page, William J. Bremner, Richard V. Clark, Mark A. Bush, Hui Zhi, Ralph B. Caricofe, Peter M. Smith, John K. Amory
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    TLDR A combination of nanomilled oral testosterone and dutasteride normalized testosterone levels in men with low testosterone and is safe for short-term use.
    In a 2007 study involving 12 healthy men with medically induced hypogonadism, researchers found that a 400-mg dose of nanomilled oral testosterone (NmT) combined with dutasteride (D) effectively normalized serum testosterone levels for 8-10 hours, suggesting its potential as a practical twice-daily therapy for male hypogonadism. The study showed that food intake had minimal impact on the pharmacokinetics of NmT+D, while it decreased the maximum observed concentration for the comparison formulation, testosterone dissolved in oil (CpT+D). Serum dihydrotestosterone (DHT) levels remained below the normal range with both formulations, and no significant adverse effects were reported, indicating the combination's feasibility and safety for short-term use.
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