N,N-Dimethylglycine sodium salt prevents human dermal papilla senescence and promotes hair growth in patients with pattern hair loss

June 2026 in “ Journal of Dermatological Science ”

Johanna Mihály, A. Lendvai, Gabriella Béke, Erika Hollósi, Jörn Michael Völker, Erik Schulze zur Wiesche, Leonardo Celleno, Maria Vittoria Tolaini, Alfredo Rossi, Lorenzo Ala, Árpád Lányi, Attila Bácsi, Tamás Bı́ró

The study examines the effects of N,N-Dimethylglycine sodium salt (DMG-Na) on hair growth and dermal papilla cell senescence. In vitro, DMG-Na was found to prevent senescence in dermal papilla cells by inhibiting senescence markers. In two clinical trials with over 300 participants, topical DMG-Na significantly improved hair density and reduced hair shedding over 6 months. The treatment was effective in both men and women, suggesting DMG-Na as a promising agent for managing hair loss by enhancing cell growth and mitigating oxidative stress.

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