Nonsegmental Vitiligo and Autoimmune Mechanism
January 2011
in “
Dermatology Research and Practice
”
TLDR Nonsegmental vitiligo is caused by the immune system attacking skin cells, often linked to other autoimmune diseases.
Nonsegmental vitiligo was characterized as a depigmented skin disorder resulting from the autoimmune loss of melanocytes, leading to progressive depigmented lesions on the skin, mucosa, and hair. It was often associated with other autoimmune diseases such as autoimmune thyroid diseases, rheumatoid arthritis, type 1 diabetes, psoriasis, and alopecia areata, suggesting a genetically determined susceptibility to multiple autoimmune disorders. The document summarized the understanding of the autoimmune pathogenesis involved in non-segmental vitiligo.
