Development of a Nude Mouse Model to Study Human Sebaceous Gland Physiology and Pathophysiology

    October 1984 in “ Journal of Clinical Investigation ”
    Mary Jean Petersen, John J. Zone, Gerald G. Krueger
    TLDR The model using human skin on mice helps study human sebaceous glands.
    This study developed a model using human face skin grafted onto nude mice to study human sebaceous gland physiology and pathophysiology. 60 adult male nude mice were used, with 29 completing the study. Androgens were administered to 21 mice, resulting in significant increases in sebaceous gland volume, cell size, and labeling index, indicating androgen stimulation. Control mice showed a decrease in gland volume and labeling index. Additionally, the application of Halowax N-34, a comedogenic substance, led to the formation of microcomedones in the grafts. This model showed potential for future research on human sebaceous glands.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 92 results

    Similar Research

    5 / 1000+ results
      Acne: Hormonal Concepts and Therapy

      research Acne: Hormonal Concepts and Therapy

      118 citations , September 2004 in “Clinics in Dermatology”
      Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.
      Hirsutism in Adolescent Females

      research Hirsutism in Adolescent Females

      13 citations , June 1989 in “Pediatric clinics of North America/˜The œPediatric clinics of North America”
      The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.
      Hormonal Therapy for Acne

      research Hormonal Therapy for Acne

      96 citations , September 2008 in “Seminars in Cutaneous Medicine and Surgery”
      Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.
      Development and Homeostasis of the Sebaceous Gland

      research Development and Homeostasis of the Sebaceous Gland

      107 citations , August 2012 in “Seminars in Cell & Developmental Biology”
      The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.