Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability

This study investigates the molecular connections between obesity and immune vulnerability by analyzing gene expression profiles across various tissues, including liver, skeletal muscle, blood, and adipose tissues. The research identifies differentially expressed genes (DEGs) and highlights the significant roles of RPL15 and RBM39 genes. It finds that cancer, particularly leukemia, lymphoma, and gastric cancer, is strongly associated with obesity. The study also reveals a host-pathogen interaction network with Influenza A virus showing the highest interaction. Key metabolites common across tissues include 2-Oxoglutarate, Adenosine, Succinate, and D-mannose. The findings suggest a link between obesity and immune-related processes, with potential overlaps in pathways related to viral infections, cytokine signaling, and insulin metabolism, indicating a possible interaction between immune and metabolic processes in obese individuals. Further experimental validation is needed to confirm these relationships.