Optical Behavior of Human Skin Substitutes: Absorbance in the 200–400 nm UV Range

The study examined the optical behavior of UGRSKIN, a bioartificial skin substitute, in the UV range (200–400 nm) over 28 days. It found that the epidermis of UGRSKIN matured over time, absorbing UV radiation similarly to native skin. Initially, absorbance was lower than native skin but surpassed it by 21 and 28 days. The study highlighted that UGRSKIN developed for 21 or 28 days could be suitable for clinical use due to its effective UV absorption and histological similarities to native skin. However, bioengineered skin lacked certain structural features of native skin, such as blood vessels. The study suggested further research to assess the biological behavior of these substitutes under continuous UV exposure.