Treatment With Oral Janus Kinase Inhibitors in Adult Patients With Alopecia Areata: A Systematic Review and Meta-Analysis

    September 2023 in “ Journal of the American Academy of Dermatology ”
    Amanda Cyntia Lima Fonseca Rodrigues, Beatriz Pessoa, Marco Antonio de Castro Olyntho, Julia Souto Faria Navarro, Bernardo Vieira Nogueira, Izabela da Mata Teixeira, Stefanie Lai
    TLDR Oral Janus kinase inhibitors are effective for treating alopecia areata in adults.
    This systematic review and meta-analysis evaluated the efficacy of oral Janus kinase inhibitors (JAKi) in treating alopecia areata (AA) in 1,010 adult patients. The study analyzed data from 9 articles and found that JAKi, including tofacitinib, ruxolitinib, baracitinib, CTP-543, ritlecitinib, and brepocitinib, achieved a clinical response success rate of 48.3% based on the Severity of Alopecia Tool (SALT) 50. The results indicate that JAKi are effective for AA treatment, but further research is needed to assess long-term effects and recurrence rates.
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