The Use of Oral Pioglitazone in the Treatment of Lichen Planopilaris

    January 2015 in “ Journal of the American Academy of Dermatology ”
    Natasha Atanaskova Mesinkovska, Alejandra Téllez, Danyelle Dawes, Melissa Piliang, Wilma Bergfeld, Natasha Atanaskova Mesinkovska, Alejandra Téllez, Danyelle Dawes, Melissa Piliang, Wilma Bergfeld
    TLDR Pioglitazone may help treat lichen planopilaris, but more research is needed.
    This study evaluated the efficacy of pioglitazone, a PPAR-γ agonist, in treating lichen planopilaris (LPP) in 22 female patients who were refractory to multiple prior therapies. The results showed that 72.7% of patients experienced marked improvement in symptoms, inflammation, and disease progression, with 27.3% noting new hair regrowth. However, side effects such as lower-extremity edema and weight gain were reported. The study concluded that PPAR-γ agonists could be a viable treatment option for LPP, targeting its inflammatory stages, but emphasized the need for a prospective, double-blind, randomized trial to confirm these findings.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  54 upvotes 1 year ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

      in Research/Science  131 upvotes 1 year ago
      Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  52 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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