Effectiveness And Safety Profile Of Oral Tofacitinib In Alopecia Areata: An Observational Study From A Tertiary Hospital

May 2026 in “ Indian Journal of Dermatology ”

Yasmeen Jabeen Bhat, Mohd Shurjeel Ul Islam, Taiba Trumboo, Kewal Krishan, Manzoor Ahmad Bhat, Saika Reyaz, Ishrat Binti Ismail, Najam U Saqib, Shuhaab Ahmad Shah, Megha Jain, Hassina Banoo

tofacitinib alopecia areata Severity of Alopecia Tool SALT score hair regrowth raised liver enzymes acne

TLDR Tofacitinib shows promise for treating alopecia areata with significant hair regrowth and mild side effects.

This observational study assessed the effectiveness and safety of oral tofacitinib in 30 patients with alopecia areata over 18 months. Results showed significant hair regrowth, with most patients experiencing a >50% reduction in the Severity of Alopecia Tool (SALT) score at 3 and 6 months. The treatment was generally well-tolerated, with mild side effects such as raised liver enzymes and acne. The study concluded that tofacitinib is a promising treatment for alopecia areata, though further research with larger sample sizes and longer follow-up is recommended to evaluate long-term efficacy and relapse rates.

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