Comparison of Efficacy of Oral Tofacitinib Versus Oral Minoxidil in Patients with Alopecia Areata

This study compared the efficacy of oral tofacitinib and oral minoxidil in treating alopecia areata in 58 patients over 12 weeks. Patients were divided into two groups, with one receiving tofacitinib and the other minoxidil. Efficacy was measured by a ≥50% reduction in the Severity of Alopecia Tool (SALT) score. Results showed that 86.2% of patients in the tofacitinib group achieved this efficacy compared to 62.1% in the minoxidil group, with a statistically significant difference (p=0.036). The mean reduction in SALT score was also significantly greater in the tofacitinib group (65.29%) compared to the minoxidil group (50.15%) (p=0.002). The study concluded that oral tofacitinib is more effective than oral minoxidil in reducing disease severity and achieving higher treatment response rates in patients with alopecia areata.