P311 Induces the Transdifferentiation of Epidermal Stem Cells to Myofibroblast-Like Cells by Stimulating Transforming Growth Factor Beta 1 Expression

    December 2016 in “ Stem Cell Research & Therapy ”
    Haisheng Li, Zhihui Yao, Weifeng He, Hongyan Gao, Yang Bai, Sisi Yang, Lu Zhang, Rixing Zhan, Jianglin Tan, Junyi Zhou, Masao Takata, Jun Wu, Gaoxing Luo
    TLDR P311 helps skin stem cells become myofibroblast-like cells, aiding wound healing.
    The study provided evidence that P311 induced the transdifferentiation of epidermal stem cells (EpSCs) into myofibroblast-like cells (MFLCs) through the TGFβ1/Smad signaling pathway. This process, termed epithelial to mesenchymal transition (EpMyT), was observed in both human and mouse models, particularly in the context of wound healing. The research demonstrated that P311 upregulation, influenced by factors such as IL-1β, IL-6, TNFα, and hypoxia, played a crucial role in this transdifferentiation by promoting TGFβ1 expression. The study also explored the mechanisms by which P311 regulated TGFβ1, including promoter methylation and activation of the TGFβ1 5'/3' UTR. This highlighted P311 as a significant regulator in cutaneous wound healing.
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