Appraisal of Paclitaxel Pros and Cons in Cancer Management and Drug Repurposing Prospects

    January 2023 in “ IntechOpen eBooks ”
    John Oluwafemi Teibo, Chioma Ejiro Irozuru, Titilade Kehinde Ayandeyi Teibo, Olabode Omotoso, Ahmad O. Babalghith, Gaber El‐Saber Batiha
    TLDR Paclitaxel is an effective cancer drug with side effects and potential new uses beyond cancer.
    Paclitaxel (Taxol) is a potent anticancer drug effective against various cancers, including breast and ovarian cancer, by obstructing mitotic spindle formation and arresting the cell cycle at the G2/M phase. Despite its efficacy, it has notable side effects such as hair loss, numbness, and bone marrow suppression, and faces resistance mechanisms like P-glycoprotein efflux pumps. Combining paclitaxel with cisplatin improves survival rates in breast cancer patients. Recent studies suggest its potential in treating non-cancer diseases like COVID-19 and fibrosis. Future advancements may enhance its biosynthesis, reduce chemo-resistance, and improve targeted delivery, potentially expanding its therapeutic uses.
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