Para Rubber Seed Oil and Its Fatty Acids Alleviate Photoaging and Maintain Cell Homeostasis

Para rubber seed oil has been identified as a promising agent for alleviating photoaging and maintaining skin homeostasis due to its beneficial fatty acids. In a study using cocultures of human HaCaT cells and dermal fibroblasts, the oil demonstrated significant photoprotection by suppressing UV-induced IL-6, IL-8, MMP-1, and MMP-9 secretions, particularly through its unsaturated C18 fatty acids. The oil, at a concentration of 100 μg/mL, was found to be safe and effective in protecting against UV damage. These findings suggest that para rubber seed oil could be developed into innovative anti-aging products, offering a sustainable solution for photoaging treatment.