Paternal Finasteride Exposure and Its Impact on Offspring Testicular Histopathology and Intracellular Junctions: The Role of Occludin and N-Cadherin
June 2026
in “
Reproductive Biology
”
Research cited in this study
24 / 24 resultsresearch Long-Term Oral Exposure to Finasteride and Different Doses of Minoxidil Induces Testicular and Epididymal Alterations in Adult Balb/c Mice
Long-term use of finasteride and minoxidil may harm male reproductive health in mice.
research The Postnatal Offspring of Finasteride-Treated Male Rats Show Altered ERα and PCNA Expression in the Liver
Finasteride use in male rats may harm their male offspring's liver function.
research Comparative Effects of Finasteride and Minoxidil on Male Reproductive Organs: A Systematic Review of In Vitro and In Vivo Evidence
Finasteride is more harmful to male reproductive health than minoxidil.
research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study
Father's finasteride use may affect son's fertility and testicular function.
research Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats
Resveratrol helps prevent finasteride-induced damage in male rats, improving reproductive function.
research Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia
Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.
research Androgenetic Alopecia: Effects of Oral Finasteride on Hormone Profile, Reproduction, and Sexual Function
Finasteride safely treats hair loss without harming hormones or reproduction, but may slightly reduce sexual function.
research Evaluation of Long-Term Efficacy of Finasteride in Korean Men with Androgenetic Alopecia Using the Basic and Specific Classification System
Finasteride effectively treats hair loss in Korean men for at least 5 years, with V type responding better.
research Infertility and Teratogenicity After Paternal Exposure to Systemic Dermatologic Medications: A Systematic Review
Some skin medications can harm male fertility, but they don't seem to cause birth defects from father's exposure.
research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome
The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.
research Finasteride Use During Pregnancy and Early Neonatal Outcome: A Case Report
Baby born healthy despite mom taking finasteride, but more research needed.
research Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring
Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.
research Adverse Effects of Finasteride: Myths and Realities. An Updated Review
Finasteride can cause sexual dysfunction, sperm changes, and affect bone density and metabolism.
research Guidelines on the Use of Finasteride in Androgenetic Alopecia
Taking 1 mg of finasteride daily can increase hair count and improve hair appearance, but it may have side effects on sexual function and a potential risk of prostate cancer. It may not be effective for postmenopausal women unless taken in higher doses.
research Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring
Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.
research Secondary Infertility Due to Use of Low-Dose Finasteride
Low-dose finasteride may cause fertility issues, but stopping it can improve sperm quality and lead to pregnancy.
research Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage
Finasteride use may cause sperm damage and infertility, stopping it can improve sperm health.
research Finasteride-Associated Male Infertility
Finasteride may cause male infertility, stopping it can help.
research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men
Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.
research Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities
Control variability makes it hard to confirm low-dose endocrine effects.
research Finasteride-Associated Male Infertility
Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats
Exposure to finasteride in the womb caused lasting reproductive issues in male rats.
research Effects of Finasteride, a Type 2 5-Alpha Reductase Inhibitor, on Fetal Development in the Rhesus Monkey (Macaca Mulatta)
Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.
research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation
Finasteride reduces male rat fertility by causing issues with copulatory plug formation.
Similar Research
5 / 1000+ results research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study
Father's finasteride use may affect son's fertility and testicular function.
research Connexin 43 expression in the testes during postnatal development of finasteride-treated male rat offspring
Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.
research Androgen levels and apoptosis in the testis during postnatal development of finasteride-treated male rat offspring
Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.
research Antioxidant enzyme expression of mRNA and protein in the epididymis of finasteride-treated male rat offspring during postnatal development
Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.
research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions
DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.