The Pressurized Skin: A Review on the Pathological Effect of Mechanical Pressure on the Skin from the Cellular Perspective

This review examines the pathological effects of mechanical pressure on the skin from a cellular perspective, focusing on how different skin cells such as fibroblasts, keratinocytes, mast cells, melanocytes, adipocytes, and stem cells respond to pressure. It highlights that mechanical pressure can disrupt skin homeostasis, leading to issues like ischemia, chronic inflammation, and impaired differentiation. The study emphasizes the importance of understanding mechanotransduction pathways, particularly the role of YAP/TAZ transcriptional cofactors in melanoma development, to better diagnose and manage pressure-related skin disorders. The review also notes that individual host factors significantly influence the development of these conditions, suggesting the need for personalized treatment approaches. Understanding these cellular mechanisms is crucial for developing therapeutic strategies to mitigate the adverse effects of mechanical pressure on the skin.