Functional Ingredient Mapping in PCOS Formulations: Hormonal Excess

The article explores the hormonal imbalance in Polycystic Ovary Syndrome (PCOS), emphasizing androgen excess and insulin resistance. It identifies functional ingredients like myo-inositol, D-chiro-inositol, spearmint extract, omega-3 fatty acids, licorice root, and vitamin D for their potential to mimic surgical effects, reduce androgen levels, and improve hormonal balance. These ingredients can modulate the hypothalamic-pituitary-ovarian axis and enhance insulin signaling, offering a non-invasive alternative to surgery. The study also highlights the role of lifestyle modifications, pharmacological therapies, and functional foods such as spearmint, flaxseed, and soy isoflavones in managing PCOS symptoms. Additionally, botanical medicines like cinnamon and licorice show promise in improving insulin sensitivity and reducing androgen levels, though caution is advised due to potential toxicity. Future research should focus on large-scale trials to confirm efficacy and establish dosing protocols.