Prevalence and Characteristics of Polycystic Ovary Syndrome in Brazilian Women: Protocol for a Nationwide Case-Control Study

October 2019 in “ BMJ Open ”

Poli Mara Spritzer, Lucas Bandeira Marchesan, Betânia Rodrigues dos Santos, Felipe Vogt Cureau, Karen Oppermann, Rosana Maria dos Reis, Rui Alberto Ferriani, Rita Vasconcellos Weiss, Ricardo M.R. Meirelles, Ana Lúcia Cândido, Fernando M. Reis

polycystic ovary syndrome PCOS Rotterdam criteria metabolic abnormalities reproductive abnormalities genetic factors epigenetic factors

TLDR PCOS is common in Brazilian women and linked to metabolic and reproductive issues.

The study investigated the prevalence and characteristics of polycystic ovary syndrome (PCOS) in Brazilian women, involving 800 women with PCOS and 400 controls. Conducted across eight university hospitals, it focused on metabolic and reproductive abnormalities, anxiety, and depression, using standardized procedures to explore clinical, genetic, and epigenetic traits. The study hypothesized regional variations in PCOS phenotypes due to differences in diet, ethnicity, and genetic backgrounds. It included physical examinations, blood and saliva samples for hormonal and genetic analyses, and pelvic ultrasounds. The comprehensive approach aimed to inform public health strategies for managing PCOS-related metabolic and reproductive issues in Brazil.

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Research cited in this study

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research The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

767 citations , September 2016 in “Human Reproduction”

Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.

research Comprehensive Overview of Polycystic Ovary Syndrome

883 citations , August 2016 in “Nature Reviews Disease Primers”

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

research Polycystic Ovary Syndrome in Salvador, Brazil: A Prevalence Study in Primary Healthcare

39 citations , January 2012 in “Reproductive Biology and Endocrinology”

About 8.5% of women in Salvador, Brazil, have Polycystic Ovary Syndrome.

research The Frequency of Metabolic Syndrome Is Higher Among Brazilian Women With PCOS, Menstrual Irregularity, and Hyperandrogenism

32 citations , November 2011 in “Reproductive Sciences”

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

666 citations , September 1977 in “British Journal of Dermatology”

Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.