The Hair Loss Encyclopedia

Polycystic Ovary Syndrome and Obesity: The Role of FTO and MC4R Gene Polymorphisms

September 2020 in “ Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi ”

Ayçıl Özturan-Şirin, Yasemin Akdevelıoğlu

Polycystic Ovary Syndrome PCOS FTO gene MC4R gene obesity insulin resistance endocrine disorder type 2 diabetes

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TLDR Genetic variations in FTO and MC4R may contribute to PCOS by affecting obesity.

This review article explored the relationship between certain gene polymorphisms, specifically FTO and MC4R, and Polycystic Ovary Syndrome (PCOS), a complex endocrine disorder. PCOS was associated with an increased risk of obesity and type 2 diabetes in women, with obesity and insulin resistance being common issues. The study suggested that genetic variations in FTO and MC4R, which were linked to obesity and metabolic disorders, might also be related to the development of PCOS through their effects on obesity/adiposity.

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Research cited in this study

4 / 4 results

MC4R Variants rs12970134 and rs17782313 Are Associated with Obese Polycystic Ovary Syndrome Patients in the Western Region of Saudi Arabia

research MC4R Variants rs12970134 and rs17782313 Are Associated with Obese Polycystic Ovary Syndrome Patients in the Western Region of Saudi Arabia

12 citations , August 2019 in “BMC Medical Genetics”

Certain MC4R gene variants are linked to higher BMI in obese women with PCOS but do not cause PCOS.

research Epidemiology, Diagnosis, and Management of Polycystic Ovary Syndrome

951 citations , December 2013 in “Clinical epidemiology”

PCOS is a common hormonal disorder in women that can be managed with lifestyle changes and various medications.

Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

research Selected Variants of the Melanocortin 4 Receptor Gene (MC4R) Do Not Confer Susceptibility to Female Pattern Hair Loss

9 citations , November 2012 in “Archives of Dermatological Research”

MC4R gene variants not linked to female hair loss.

Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.