Genotypic and Phenotypic Study of PDCD4 Gene Concerning Micro RNA-21 and Micro RNA-449b Polymorphism in Breast Cancer

    January 2025 in “ Iraqi Journal of Science ”
    Mohammed S. Hussein, Mohammed Q. Al‐Ani, Fadhel M. Lafta
    TLDR PDCD4 protein levels, affected by genetics and breastfeeding, may predict breast cancer treatment response.
    This study investigated the role of PDCD4 gene polymorphisms and microRNAs miR-21 and miR-449b in breast cancer among 180 Iraqi women, including 120 breast cancer patients and 60 healthy controls. Significant associations were found between miR-449b polymorphism and PDCD4 serum levels, with different levels observed in treatment, post-treatment, and control groups. Breastfeeding was shown to significantly increase PDCD4 serum levels, suggesting its potential role in breast cancer prevention. The study concludes that PDCD4 protein levels, influenced by genetic polymorphisms and breastfeeding, could serve as a predictive marker for treatment response in breast cancer.
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