TLDR Polydeoxyribonucleotides may help with healing and anti-aging, but more research is needed.
Polydeoxyribonucleotides (PDRN), derived from fish sperm DNA, show promise in regenerative and aesthetic medicine due to their ability to stimulate angiogenesis, collagen synthesis, and exhibit anti-inflammatory effects. Recent research highlights their effectiveness in anti-aging treatments, scar and stretch mark reduction, and addressing hair loss. However, further long-term clinical studies are necessary to fully assess the safety and efficacy of PDRN therapies.
14 citations
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May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.
April 2025 in “Journal of Skin and Stem Cell” PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
February 2026 in “Journal of Cutaneous and Aesthetic Surgery” Most emerging dermatological treatments lack strong evidence and require more research.
7 citations
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January 2025 in “Current Issues in Molecular Biology” Microbial-derived polydeoxyribonucleotide is a better and more sustainable alternative to salmon-based versions for healing and immune support.
80 citations
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April 2017 in “Frontiers in Pharmacology” PDRN helps repair tissue and improve wound healing with a high safety profile.
