Pediatric Sjögren’s Syndrome: Focus on Ocular Involvement and Diagnostic Challenges

    June 2025 in “ Medicina ”
    Emanuela Del Giudice, Maria Carmela Saturno, Maria Grazia Fiorino, Danilo Iannetta, Luca Spadea, Vanessa Martucci, Alessia Marcellino, Mariateresa Sanseviero, Angela Mauro, Sandra Cinzia Carlesimo, Nicola Nante, Giovanni Guarducci, Leopoldo Spadea, Riccardo Lubrano, Maria Pia Paroli
    TLDR Early diagnosis using eye tests and lab markers can improve treatment for pediatric Sjögren's syndrome.
    This study on pediatric Sjögren's syndrome, involving six patients, emphasizes the significance of early diagnosis through a combination of clinical, ophthalmological, and laboratory markers. Ocular assessments revealed consistent tear film instability and Meibomian gland dysfunction, while systemic symptoms included arthralgia and Raynaud's phenomenon, with frequent seropositivity for ANA and anti-SSA/Ro antibodies. The study concludes that integrating tear break-up time (TBUT) and slit-lamp evaluations with serological and histopathological data can improve diagnostic accuracy and facilitate timely interventions to prevent long-term complications in children.
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