Penetration And Distribution In Human Skin Focusing On The Hair Follicle

The document discussed the potential of topical drug delivery to target specific skin regions like hair follicles, sweat, and sebaceous glands, which could enhance drug concentration at the action site while minimizing systemic circulation. This approach was particularly relevant for treating skin conditions such as acne, cancer, and alopecia, and for cosmetic purposes. Two main strategies to improve local delivery were highlighted: selecting appropriate formulations with carriers and additives, and choosing drug candidates based on their physicochemical properties. When formulation adjustments were not possible, the drug's inherent properties determined the effectiveness of delivery and targeting.