Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling

The study highlights the importance of PPAR signaling in diabetic foot ulcer (DFU) healing, where its inhibition is associated with vascular dysfunction. Activation of the PPARs/SHH-mitochondrial axis is shown to significantly improve endothelial cell metabolism and promote angiogenesis. These findings offer valuable insights into the molecular mechanisms underlying diabetic wound healing and suggest the clinical potential of PPAR agonists as a treatment for DFUs.