Photo-Responsive Ascorbic Acid-Modified Ag<sub>2</sub>S–ZnS Heteronanostructure Dropping pH to Trigger Synergistic Antibacterial and Bohr Effects for Accelerating Infected Wound Healing

    February 2024 in “ ACS Applied Materials & Interfaces ”
    L. Yang, Wen‐Jyun Wang, Wanting Huang, Liu‐Chun Wang, Ming-Chien Hsu, Chung‐Dann Kan, Chun-Yung Huang, Tak‐Wah Wong, Weipeng Li
    TLDR A new light-activated treatment speeds up healing of infected wounds without antibiotics.
    This study developed a nonantibiotic approach using matchstick-like Ag<sub>2</sub>S-ZnS heteronanostructures (HNSs) modified with ascorbic acid to treat wounds infected by multidrug-resistant bacteria. The HNSs generate reactive oxygen species and release silver ions upon light exposure, which decreases local pH and enhances antibacterial effects. The PEGylated Ag<sub>2</sub>S-ZnS@TGA-AA HNSs demonstrated synergistic antibacterial activity against Gram-negative <i>Escherichia coli</i> and Gram-positive methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). In tests, MRSA-infected wounds treated with these HNSs under light exposure healed significantly faster, highlighting their potential in accelerating wound healing through antibacterial and Bohr effects.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results